Abstract: Objective To investigate the application of contrast-enhanced ultrasound (CEUS) quantitative parameters in differential diagnosis of ovarian epithelial tumors and its correlation with neovascularization in malignant transformation. 
Methods In total, 102 patients with ovarian epithelial tumors were selected and divided into malignant group (n=51) and benign group (n=51). CEUS parameters of the two groups were collected, and receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic value of CEUS parameters for the differential diagnosis of ovarian epithelial tumors. Logistic regression analysis was used to investigate the relationship between CEUS parameters and the incidence of ovarian epithelial cancer. Correlation analysis was used to investigate the relationship between CEUS parameters, microvascular density (MVD), International Federation of Gynecology and Obstetrics(FIGO) stage, differentiation degree, and lymph node metastasis in the malignant group, as well as the relationship between CEUS parameters and MVD in the malignant group. 
Results The initial increase time and peak time in the malignant group were lower than those in the benign group, while the peak intensity, enhancement rate, and area under the time-intensity curve were higher than those in the benign group(P＜0.05). The area under the ROC curve (AUC) of various CEUS parameters in combination in diagnosing ovarian epithelial tumors was greater than that of each parameter alone (P＜0.05). Logistic regression results showed that the initial increase time, peak time, peak intensity, enhancement rate, and area under the time-intensity curve were all associated with the development of ovarian epithelial cancer (P＜0.05).The initial increase time, peak time in the malignant group were negatively correlated with FIGO stage and lymph node metastasis, and positively correlated with differentiation degree, while peak intensity, enhancement rate, area under the time-intensity curve, and MVD were positively correlated with FIGO stage and lymph node metastasis, and negatively correlated with differentiation degree (P＜0.05). The initial increase time, peak time in the malignant group were negatively correlated with MVD, while PI, enhancement rate, and area under the time-intensity curve were positively correlated with MVD (P＜0.05). 
Conclusion CEUS quantitative parameters have certain diagnostic value in the identification of ovarian epithelial tumors, and malignant tumors in patients are closely related to FIGO stage, lymph node metastasis, degree of differentiation, and neovascularization, which can provide reference for clinical identification of ovarian epithelial tumors. 

Key words: ovarian neoplasms, contrast-enhanced ultrasound, quantitative parameter