Abstract: Objective To explore the predictive efficacy of combined detection of C-reactive protein (CRP), procalcitonin (PCT), and γ-glutamyltransferase (γ-GT) for neonatal hyperbilirubinemia complicated with infection. 
Methods Eighty children with hyperbilirubinemia were selected and divided into the infection group (n=17) and the non-infection group (n=63) according to their prognosis and outcome. The serum neutrophil ratio, serum amyloid A, platelet count, CRP, PCT, and γ-GT levels in the two groups were compared. Factors influencing the incidence of infection in children with hyperbilirubinemia were analyzed. The predictive efficacy of detection of CRP, PCT, γ-GT alone and in combination for neonatal hyperbilirubinemia complicated with infection was evaluated. 
Results Among the 80 children with hyperbilirubinemia, 17 cases (20.99%) were complicated with infection. The serum levels of CRP, PCT, and γ-GT in the infection group were significantly higher than those in the non-infection group (P＜0.05). Logistic regression analysis showed that elevated serum levels of CRP was risk factors for infection in children with hyperbilirubinemia (P＜0.05). The results of receiver operating characteristic (ROC) analysis showed that the area under the ROC curve (AUC) of serum levels of CRP, PCT, and γ-GT alone or in combination in predicting infection in children with hyperbilirubinemia was 0.713 (95%CI: 0.601-0.827), 0.707 (95%CI: 0.602-0.813), 0.673 (95%CI: 0.551-0.795), and 0.802 (95%CI: 0.713-0.912), respectively. Combined detection had a higher predictive efficacy than single detection (P＜0.05). 
Conclusion Serum levels of CRP, PCT, and γ-GT are influential factors in neonatal hyperbilirubinemia complicated with infection, and combined detection exhibits higher predictive efficacy in neonatal hyperbilirubinemia complicated with infection. 

Key words: hyperbilirubinemia, C-reactive protein, procalcitonin, γ- glutamyltransferase