Abstract: Objective To investigate the effect of budesonide combined with endoscopic surgery on chronic dacryocystitis. 
Methods In total, 80 patients (80 eyes) with chronic dacryocystitis were enrolled in a prospective single-blind study and randomly divided in to budesonide group (n=40) and control group (n=40). All patients underwent nasal endoscopic dacryocystorhinostomy. Budesonide nasal spray was used for 3 months in the budesonide group, and physiological seawater was used for 3 months in the control group. The surgical effect, Lund-Kenndey score and complications of the two groups were compared. 
Results At 6 months after follow-up, the effective rate of budesonide group was better than that of the control group (P＜0.05). At 3 months after surgery, the Lund-Kenndey score in the two groups was lower than that before surgery, and lower in the budesonide group than in the control group (P＜0.05). The incidence of complications in the budesonide group was lower than that in the control group (5% vs. 20%, P＜0.05). 
Conclusion The application of budesonide nasal spray after nasal endoscopic dacryocystorhinostomy is safe and effective, with a higher success rate, a lower probability of anastomotic adhesion and granuloma, and does not increase the risk of postoperative infection. 

Key words: dacryocystitis, budesonide, dacryocystorhinostomy