Abstract: Objective To investigate the relationship of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR-2) expression on the wound surface with postoperative wound healing time in patients with stage Ⅱ anal fissure. 
Methods A total of 104 patients with stage Ⅱ anal fissure who underwent surgical treatment in our hospital were selected as the research subjects. The levels of VEGF and VEGFR-2 collected from the granulation tissue of the wound edge were detected at dressing change at one week after surgery. The postoperative wound healing time of patients was statistically analyzed, and the patients were divided into three groups according to the third percentile of postoperative wound healing time of patients. The clinical data and the levels of VEGF and VEGFR-2 on the wound surface in the three groups were compared. The correlation of VEGF and VEGFR-2 with postoperative wound healing time as well as the influencing factors of postoperative wound healing time was analyzed. 
Results There were significant differences in VEGF and VEGFR-2 levels among the three groups (P＜0.05). The lower the levels of VEGF and VEGFR-2 on the wound surface, the longer the wound healing time (P＜0.05). VEGF and VEGFR-2 were negatively correlated with postoperative wound healing time (P＜0.05). Constipation, duration of operation, open incision, wound longitudinal diameter and wound transverse diameter were independent risk factors for postoperative wound healing time, and VEGF and VEGFR-2 were independent protective factors for postoperative wound healing time (P＜0.05). 
Conclusion The levels of VEGF and VEGFR-2 on the wound surface are negatively correlated with the wound healing time after surgery for stage Ⅱ anal fissure. The two indexes can be used to determine the wound healing of patients, thus providing guidance for the improvement of postoperative treatment plans.  

Key words: anal fissure, vascular endothelial growth factor receptor-2, treatment outcome