Abstract: Objective To explore the effect of 1-h, 3-h and 6-h cluster therapy on the short-term prognosis of patients with septic shock.  
Methods A retrospective study was conducted on case data of 249 patients with septic shock. Baseline characteristics and pathological data of enrolled patients were collected and categorized into survival and non-survival groups based on prognosis outcomes. The completion status of 1-h, 3-h and 6-h cluster therapy between the two groups was analyzed. Logistic multivariate regression analysis was performed to screen for prognostic factors of patients with septic shock. 
Results Among the 249 patients with septic shock, there were 74 deaths within 28 days, resulting in a mortality rate of 29.72%. Specifically, the number of patients with completion rates of 1-h, 3-h, and 6-h cluster therapy were 18 (24.32%), 44 (59.46%), and 12 (16.22%), respectively. Survival was observed in 175 (70.28%) patients. In the non-survival group, the Acute Physiology and Chronic Health Evaluation Ⅱ (APACHEⅡ) score was higher, and the initiation of antibiotic use was later compared with that of the survival group. Additionally, the proportion of patients with completion of 1-h cluster therapy, reevaluation of elevated lactate levels, and normal central venous pressure values was lower than that in the survival group (P＜0.05). The results of multivariate Logistic regression analysis indicated that APACHEⅡ score (OR=3.777, 95%CI: 2.133-6.689), duration of antibiotic use (OR=3.053, 95%CI: 1.723-5.406), reevaluation of elevated lactate levels (OR=0.337, 95%CI: 0.185-0.613), completion of 1-h cluster therapy (OR=0.404, 95%CI: 0.219-0.745), and normal central venous pressure values (OR=0.291, 95%CI: 0.165-0.511) were all factors influencing the prognosis of patients with septic shock (P＜0.05). 
Conclusion The completion of 1 h cluster therapy is helpful to improve the short-term prognosis of patients with septic shock. 

Key words: shock, septic, cluster therapy, prognosis