Abstract: Objective To explore the preliminary clinical effect of periwound flap in the treatment of diabetic foot. 
Methods From January to June 2022, 52 patients diagnosed with diabetic foot in Beijing Luhe Hospital Affiliated to Capital Medical University were retrospectively analyzed. All patients underwent repair of diabetic foot wound susing periwound flaps. The general data were analyzed, and primary wound healing rate, ulcer reappear rate, ulcer recurrence rate, ankle amputation rate, incidence of adverse events, and wound healing time were compared among the groups. The risk factors affecting the prognosis of patients were analyzed. 
Results The overall primary wound healing rate was 96.20%, the ulcer reappear rate was 9.60%, the ulcer recurrence rate was 3.80%, the ankle amputation rate was 1.90%, the incidence of adverse events was 11.50%, and the healing time was （44.52±14.85） d. The primary wound healing rate of patients with cerebral infarction (83.30%) was significantly lower than that of patients without cerebral infarction (100%, P=0.050). The recurrence rate of ulcer in patients aged ≤60 years was 28.60%, which was significantly higher than 2.60% in patients aged >60 years (P=0.022). The recurrence rate of ulcer in patients with coronary heart disease(CHD) (16.70%) was significantly higher than that in patients without CHD (0%) (P=0.050). The wound healing time of patients with Wagner3 was （37.32±10.54） d, which was significantly shorter than that of patients with Wagner4 ［(48.59±13.07） d, P=0.001］. There was no significant difference in the prognostic indicators between ischemic and non-ischemic diabetic foot. Regression analysis showed that age ≤60 years was an independent risk factor for ulcer recurrence (P=0.022). Higher Wagner grade was an independent risk factor for prolonged wound healing time (P=0.001). 
Conclusion Periwound flap represents an effective method for rapid closure of diabetic foot wounds. In the meantime, attention should be paid to the non-foot comorbidities of diabetic foot and the diagnosis and management of peripheral vascular diseases in these patients. 

Key words: diabetic foot, periwound flap, wound repair, revascularization