Effect of raltitrexed combined oxaliplantin as secondline chemotherapy for advanced gastric cardial carcinoma

doi:10.3969/j.issn.10073205.2016.01.007

Abstract

Abstract: Objective Toevaluatetheefficiency andtoxicity ofraltitrexedcombined
qxaliplantinassecond-linechemotherapyintreatmentofadvancedgastriccardialcarcinoma.
Methods Fifty-eightpatientsofadvancedgastriccardialcarcinomawhohadreceivedfirst-line
therapybuthadrelapsedorprogressedweregiven3mg
/ m
2 ofraltitrexed ,
intravenousbolus ,
d1 , 21daysasacycle , combinedoxaliplantin130mg / m
2 ,
intravenousinfusion>3h , d1 , 21
daysasacycle.Theanalysislastedatleasttwocyclessoastoevaluatetheshort-termefficiency
andadversereactions.Aftertwocyclesofchemotherapy , theefficiencyandtoxicity were
evaluated.Atotalofsixcycleswereappliedunlesstherewereevidenceofdiseaseprogressionor
intoleranceoftreatment.Results All58patientswereevaluable , includingcompleteresponse2
cases , accountingfor3.4% , partialresponse16cases , accountingfor27.6% ; stabledisease14
cases , accountingfor24.1% ; progressivedisease26cases , 44.8%.Overallresponseratewas
31.0% , diseasecontrolrate55.2% , themiddletimetoprogression6.9months.Themainside
effects were myelosuppression , gastrointestinal reactions , aminotransferase abnormality ,
peripheralneurotoxicityandsoon.Thewholegrouphadnotreatment-relateddeathinpatients
and no toxicity due to the delay chemotherapy.Conclusion Raltitrexed as second-line chemotherapyintreatmentofadvancedgastriccardialcarcinomaiseffectiveandwelltolerated.

Key words: stomach neoplasms, antineoplastic combined chemotherapy protocols, treatment outcome

LV Huilai1，ZHANG Li2，WEN Shiwang1，LI Yong1，ZHANG Yuefeng1，TIAN Ziqiang1*. Effect of raltitrexed combined oxaliplantin as secondline chemotherapy for advanced gastric cardial carcinoma[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2016.01.007.

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Effect of raltitrexed combined oxaliplantin as secondline chemotherapy for advanced gastric cardial carcinoma

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