Abstract: Objective To explore the therapeutic effect and prognostic effect of Ubenimex capsule combined with radiotherapy in patients with cervical cancer. 
Methods A total of 60 patients with cervical cancer admitted to our hospital were randomly divided into radiotherapy group and combination group, with 30 cases in each group. Patients in the radiotherapy group received radiotherapy, and patients in the combination group received Ubenimex capsule combined with radiotherapy. Human telomerase reverse transcriptase(hTERT) and human papillomavirus(HPV) were detected by mucus assay. Receptor for activated C kinase 1(RACK1), microRNA-198(miR-198), microRNA-329-3p(miR-329-3p), classⅡ transactivators(CIITA), gamma-interferon-inducible lysosomal thiol reductase(GILT), and asparagine endopeptidase(LGN) were detected by RT-PCR. The quality of life between two groups was compared. Serum carbohydrate antigen 724(CA724), carcinoembryonic antigen(CEA) and squamous cell carcinoma associated antigen(SCC-Ag) were detected by enzyme-linked immunosorbent assay(ELISA). Clinical efficacy, adverse reactions and survival were evaluated. 
Results Compared with the radiotherapy group, the levels of HPV, hTERT, RACK1, miR-198, CIITA, GILT, FACT-G score, FACT-CX score, CA724, CEA and SCC-Ag in the combination group were lower, while the expression levels of miR-329-3p and LGMN were higher(P＜0.05). Compared with the radiotherapy group, the total response rate, median survival time and survival rate were higher in the combination group(P＜0.05). 
Conclusion Ubenimex capsule combined with radiotherapy can improve the expression of RACK1, miR-198, miR-329-3p and the level of tumor markers in patients, and promote the recovery of patients, ensuring long survival of patients and good therapeutic effect.

Key words: uterine cervical neoplasms, ubenimex capsule, chemoradiotherapy