Abstract: Abstract］  ObjectiveTo investigate the value of microRNA92a combined with pepsinogen(PG) in the diagnosis of gastric carcinoma. MethodsSixty cases of gastric cancer, 141 cases of chronic atrophic gastritis and 162 cases of chronic nonatrophic gastritis were adopted，using realtime PCR assay for detection of micro RNA92a and using immune colloidal gold technique for measuring PG. The sensitivity and specificity of miRNA92a, PG and miRNA92a combined with PG in the diagnosis of gastric cancer were calculated respectively. ResultsThe expression of miRNA92a in chronic atrophic gastritis group and non atrophic gastritis group was lower than gastric cancer group. The expression level of plasma miRNA92a in chronic non atrophic gastritis group was lower than chronic atrophic gastritis group(P＜005). The expression level of PG Ⅰ and PG Ⅰ/PGⅡ in gastric cancer group were lower than chronic atrophic gastritis group and chronic non atrophic gastritis group. The value of PG Ⅰ/PGⅡ in chronic atrophic gastritis group was lower than non atrophic gastritis group(P＜005). There was not significant between chronic atrophic gastritis and chronic atrophic gastritis group(P＞005). microRNA92a sensitivity in the diagnosis of gastric cancer and specificity were 85.70% and 70.8%. PG in sensitivity and specificity in the diagnosis of gastric cancer were 75.80% and 84.90%. The sensitivity of micro RNA92a combined with PG diagnosis of gastric cancer and precancerous lesion and the specificity was 86.49%, the specificity was 89.32%. Conclusionmicro RNA92a combined with PG was better than single detection in diagnosis of gastric cancer.

Key words: stomach neoplasms, microRNAs, pepsinogen