Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the association of serum adiponectin(APN) levels with cognitive function in patients with obstructive sleep apneahypopnea syndrome(OSAHS).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 94 patients with OSAHS cared at our hospital and 93 healthy controls without OSAHS from the medical examination center were recruited. Data on demographic characteristics and clinical parameters were collected. APN was measured by enzymes linked immunosorbent assay(ELISA). Cognitive performance was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS) and MiniMental State Examinatlon(MMSE).
〖HTH〗〖WTHZ〗Results〖HTSS〗〓①Compared with controls, Serum APN levels and RBANS scores including immediate memory, visuospatial/constructional, attention, delayed memory and total scores were all lower in patients with OSAHS. ②APN was negatively correlated with body mass index, Homeostasis model assessment for insulin resistance, apnea hypoventilation index and % nighttime spent with oxygen saturation<90%, but postively correlated with mean oxygen saturation. ③In patients with OSAHS, cognitive impairment group had lower levels of APN than noncognitive impairment group. ④Logistic regression analysis showed that APN was a protective factor of cognitive function in patients with OSAHS(OR=0.212, P=0.008); ⑤APN was postively correlated with RBANS scores including immediate memory, attention, delayed memory and total scores in patients with OSAHS.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Patients with OSAHS have lower serum APN levels and worse cognitive performance, and serum APN was postively correlated with their cognitive performance, suggesting that serum APN may be involved in cognitive deficits of patients with OSAHS.

Key words: sleep apnea, obstructive； adiponectin, cognition