Abstract: ［Abstract］ Objective〖HTSS〗〓To observe the effects of Resveratrol(RES) on diabetic rats with retinopathy, and to explore its mechanism.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Fortyfive cleaning degree healthy male SD rats were randomly divided into 3 groups, control group,model group and RES group(n=15/group). The diabetic rats model were established by streptozotocin intraperitoneal injection. One week after modeling, rats in RES group was administrated intraperitoneally with RES(40 mg/kg, 10 mL/kg) once daily for consecutive 6 weeks. After treatment, the blood glucose and body weight of different groups were measured. The expression of tumor necrosis factor alpha(TNFα) and interleukin1β(IL1β） in retina of different groups were detected by enzyme linked immunosorbent assay(ELISA). The expression of vascular endothelial growth factor(VEGF), hypoxia inducible factor1α(HIF1α), methane dicarboxylic aldehyde(MDA) and superoxide dismutase(SOD) in serum of different groups were detected by ELISA.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The blood glucose of model group and RES group was higher than control group, body weight of model group and RES group was lower than control group(P<0.05), there were no significantly difference between model group and RES group(P>0.05). The expressions of TNFα, IL1β, VEGF, HIF1α and MDA in model group and RES group were higher than that of control group. The e expressions of TNFα, IL1β, VEGF, HIF1α and MDA in RES group were lower than that of model group(P<0.05). The expression of SOD in model group and RES group was lower than that of control group. The expression of SOD in RES group was higher than that of model group(P<0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓RES could inhibit inflammatory reaction, suppresses HIF1α/VEGF pathway and reduces oxidative stress injury, then ameliorates vascular lesions in diabetic retina.

Key words: diabetic retinopathy, Resveratrol, rats, streptozotocin