Abstract: ［Abstract］〓Objective〖HTSS〗〓To evaluate the efficacy, analgesic effect and the safety of nalbuphine combined with propofol in outpatient induced abortion.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 120 patients with ASA grade Ⅰ to Ⅱ induced abortion were randomly divided into control group and experimental group, 60 cases in each group. The experimental group was intravenously injected with 0.2 mg/kg nabuprofen hydrochloride(diluted to 2 mL), and intravenously injected with propofol 2.0 mg/kg one minute later. The control group received intravenous injection of 2 mL of normal saline as control, and 1 minutes after intravenous injection of propofol 3.0 mg/kg. The anesthesia effect, propofol dosage during operation, recovery time, uterine contractile pain score at 5 and 30 minutes after operation and adverse reactions were observed. Systolic blood pressure(SBP), diastolic blood pressure(DBP), heart rate(HR) and pulse oxygen saturation(SpO2) were recorded at T0(entering the room), T1(the eyelash reaction disappeared), T2(at the beginning of the operation), T3(at the end of the operation)and T4(5 minutes after the operation).
〖HTH〗〖WTHZ〗Results〖HTSS〗〓SBP and DBP in the two groups showed a trend of decreasing first and then increasing, the difference was statistically significant between the time points(P＜005). There was no significant difference in the interaction between groups and time points(P＞005), and there was no significant difference between the two groups(P＞005). HR of the two groups showed a trend of decreasing first and then increasing, and the interaction between groups and time points(P＜005) and between groups was statistically significant(P＜005), but there was no significant difference between the two groups(P＞005). SpO2 of the two groups showed a gradual upward trend, the difference was statistically significant between time points(P＜005), there were no significant difference in the interaction between groups and time points and between groups(P＞005). The dosage of propofol in the experimental group was less than that in the control group, and the recovery time was shorter than that in the control group(P＜0.05). The pain score of uterine contraction in the experimental group was significantly lower than that in the control group at 5 and 30 minutes after operation, and the satisfaction was better than that in the control group(P＜005). There was no significant difference in the incidence of complications between the 2 groups(P＞0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Hydrochloride nalbuphine combined with propofol is a safe and effective anesthesia method in artificial abortion. Hydrochloride nalbuphine markedly reduced the dosage of propofol, showed an outstand analgesic effect on postoperative uterine contraction pain without obvious adverse reactions.

Key words: abortion, induced； nalbuphine, propofol