Abstract: Objective To explore the safety and effectiveness of remifentanil combined with propofol target-controlled infusion and propofol combined with sevoflurane inhalation general anesthesia for interventional treatment of congenital heart disease(CHD) in children. 
Methods A total of 120 children who underwent interventional treatment for CHD in our hospital were selected and randomly divided into the propofol and remifentanil(PR) group(n=60) and the propofol and sevoflurane(PS) group(n=60). Anesthesia induction was performed in the PR group with remifentanil(4.0 μg/L) and propofol(4.0 mg/L). Anesthesia was maintained with propofol(2.5～4.0 mg/L) and remifentanil(4.0 μg/L). The concentration of propofol was adjusted to maintain A-line ARX index at 25～30. Anesthesia induction was performed in the PS group using propofol(2 mg/kg) and sevoflurane inhalation throμgh a laryngeal mask, and the concentration was increased from 2%(maximum concentration 7%). Anesthesia maintenance was kept using propofol(6 mg·kg-1·h-1) and sevoflurane(1% to 3%). The heart rate(HR), respiratory rate(RR), mean arterial pressure(MAP), blood oxygen saturation(SpO2), jugular bulb venousoxygen saturation(S-jvO2) and cerebral arterial venous oxygen content difference(Da-jvO2) before induction(T0), at laryngeal mask insertion(T1), at 3 min after laryngeal mask insertion(T2), immediately after operation(T3), and at laryngeal mask removal(T4), as well as extubation time, recovery time, residence time in anesthesia recovery room, postoperative hospital stay, complication and rate were compared between the two groups. 
Results ①With the change of time, HR, RR, and MAP of the two groups initially decreased and then increased. The differences between groups, time points and interactions between groups and time points were statistically significant(P＜0.05). ②With the change of time, S-jvO2 and Da-jvO2 in the two groups initially decreased and then increased. The differences between the groups, the time points, and the interaction between groups and time points were all statistically significant(P＜0.05). ③There were no significant difference in residence time in anesthesia recovery room and hospital stay between two groups(P＞0.05). The extubation time of the PS group was shorter than that of the PR group(P＜0.05). ④The total incidence of complications in the two groups was 13.33% and 10.00% respectively, and the difference was not statistically significant(P＞0.05). 
Conclusion The intraoperative vital signs using propofol combined with sevoflurane inhalation general anesthesia for CHD in children undergoing interventional surgery are more stable than those using remifentanil combined with propofol target-controlled infusion, and it is more conducive to the balance of cerebral oxygen supply and demand.

Key words: heart disease, propofol, sevoflurane