Abstract: ［Abstract］ Objective〖HTSS〗〓 To evaluate the relationship of interleukin4（IL4） rs2070874 gene polymorphism with H.pylori infection and susceptibility to gastric cancer in different groups of the Han nationality adults.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 311 subjects were recruited and divided into three groups: 105 H. pylori positive, 103 gastric cancer people, and 103 H. pylori negative. The peripheral venous bloods were extracted and direct sequencing method were used for IL4 rs2070874 gene polymorphism analysis. 
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The main genotype of IL4 rs2070874 in H. pylori infection group was TT type, accounting for 55.24% of the total, TC type was the main genotype in gastric cancer group, accounting for 55.34% of the total, and TT type was the main genotype in noninfection group, accounting for 44.66% of the total. TC genotype in gastric cancer group was higher than that in H. pylori infection group and noninfection group, and the genotype distribution had significant difference(P＜001).But no significant difference was found between H. pylori positive and negative group. T was the high expression gene of this locus and no different frequency was founded in the three groups(P＞005). The C frequency of IL4rs2070874 in Han nationality adults was 0.3215.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓IL4 rs2070874 gene polymorphism may be associated with gastric cancer susceptibility, but not with H. pylori infection, TC gene may increase the risk of gastric cancer.

Key words: stomach neoplasm, interleukin4, helicobacter pylori