Abstract: ABSTRACT:Objective To evaluate the effects of grid photocoagulation combined with panretinal laser photocoagulation treatment for fiber membrane of retinal neovascularization in proliferative diabetic retinopathy (PDR)patients.Methods A total of 138 eyes of 87 patients, who were diagnosed as PDR,were enrolled in this study.All patients were evaluated by fundus fluorescein angiography (FFA ) examination.According FFA examination,87 patients were separated into two groups:retinal neovascularization fiber membrane formation not associated with peripheral vascular traction distorted group (group A)and retinal neovascularization fiber membrane formation associated with peripheral vascular traction distorted group (group B).Each group was again divided into two subgroups:group Ⅰ (retinal neovascularization fiber membrane formation range less than the 2PD)and group Ⅱ (the formation of retinal neovascularization fiber membrane greater than 2PD).The patients of group A were treated with macular laser grid photocoagulation first,and one week later treated with panretinal laser photocoagulation.The patients of group B were treated the same with group A firstly,and then according with the FFA and visual acuity to formulate timely and individual panretinal laser photocoagulation treatment. The best corrected visual acuity,fundus changes,and FFA examination were recorded before the laser surgery and laser treatment at least six months.Results The total effective rate in visual acuity of group AⅠ accounted for 92.86%,and that of group A Ⅱ 94.87%;group BⅠ91.30%, group B Ⅱ 85.29% .The treatment efficiency showed no significant difference between the four groups(P >0.05).The treatment efficiency of DR retinal lesions was total 92.96% in group AⅠ, 84.62%in group A Ⅱ ,91.30% in group BⅠ,73.53% in group B Ⅱ.The treatment efficiency showed no statistic difference between the four groups (P > 0.05 ).The absorption of retinal edema,exudation and bleeding were sped up after the treatment with laser photocoagulation.The effect was 95.23% in group AⅠ,84.62% in group A Ⅱ ,95.65% in group BⅠ,79.41% in group B Ⅱ.And the treatment efficiency did not have significant difference between the four groups (P > 0.05 ).Conclusion The prognosis of different staging PDR with retinal laser photocoagulation treatment is different,right time of photocoagulation treatment is important for the stability of visual acuity and retinopathy.

Key words: diabetic retinopathy, light coagulation, retinal neovascularization