Abstract: Objective This study observes the effect of paclitaxel on liver cancer cell proliferation by inhibiting KIF14 expression in liver cancer cells. Methods Silenced KIF14 expression in liver cancer cells by RNA interference,these cells were delt by paclitaxel and the proliferation ability of liver cancer cells was determined by MTT test. Results Silence KIF14 expression in liver cancer cells enhanced the cells sensitivity to paclitaxel. Conclusion KIF14 is important in the process of drug resistance produced by human hepatocellular carcinoma cells. Further study on its mechanism can provide theoretical basis for seeking the effective ways to overcome drug resistance of liver cancer.

Key words: liver neoplasms, kinesin, antineoplastic agents