Bacteria detection in sputum and analysis of bacterial resistance in childhood pneumonia

doi:10.3969/j.issn.1007-3205.2016.01.011

Abstract

Abstract: ] Objective Toinvestigatebacterialinfectionanddrugresistanceinchildrenwith
community-acquiredpneumonia ( CAP ), andtoprovidethebasisforearlyclinicaldrugtherapy.
Methods Theworkinvestigated1328CAPaffectedinfantsinourhospital.Theirsputum
samplesweregotthroughasepticnegativepressureattractionandthenbacterialcultivationwas
madewithagardilution.ThebacterialdrugresistancewasmeasuredthroughbothKirby-Bauer
discdiffusionandbrothdilutionmethods.Results Theresultsrevealed676positiveinfantsand
thepositiverate50.9%.Thetopfivebacteriaranged : Streptococcuspneumonia ( 204 / 680 ),
Klebsiellapneumonia ( 130 / 680 , including8 ESBLs ), Escherichiacoli ( 104 / 680 , including5
ESBLs ), Staphylococcusaureus ( 88 / 680 , including10MRAS ), andHaemophilusinfluenzae ( 36 /
680 ) .TheanalysisofantibioticsusceptibilitytestrevealedthatStreptococcuspneumoniaingram-
positivebacteriashowed19.6%resistanceratetothepenicillin ; Thedrugresistanceratewere
12.7% toamoxicillin / clavulanaicacid.Meanwhile , Staphylococcusaureusshowed morethan
90.0% drugresistanceratetopenicillinandamoxicillin / clavulanaicacid.Ontheotherhand ,
cefotaximeandcotrimoxazole.But , theyshowedhighsensitivitytomeropenem.Conclusion
Theobservationsrevealedthat CAPin ourhospital was mainlyinduced by Streptococcus
pneumonia , Klebsiella
pnueumoniae , Escherichia coli , Staphylococcus
aureus. Most
streptococcuspneumoniaaresensitivetopenicillinandamoxicillinclavulanatepotassium.The
resultsareimportantfortestingpathogenicandusingantibioticreasonably , althoughthesputum
samplesarelimitedtothejudgmentofpneumoniaetiology.
gram-negativebacteriashowedhighdrugresistanceratetoampicillin , cephazolin , ceftriaxone ,

Key words: pneumonia , anti-bacterialagents , drugfastness

HUANG Guangli,SHI Qingsheng,CHEN Haixia,CHE Xiangyu,LI Junqin. Bacteria detection in sputum and analysis of bacterial resistance in childhood pneumonia[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.1007-3205.2016.01.011.

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Bacteria detection in sputum and analysis of bacterial resistance in childhood pneumonia

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