Abstract: [
Abstract ] Objective Toinvestigatetheeffectofcoronaryinterventionontheprognosisof
patientswithacutemyocardialinfarctiontreatedbypercutaneouscoronaryintervention ( PCI ) .
Methods Two hundredcasesofpatients with acute myocardialinfarction wererandomly
selected , whoweredividedintothreegroups , namelyintravenousgroup ( n =70 ), intracoronary
group ( n =70 ) andcontrolgroup ( n =60 ) .Theintravenousgroupweregivenintravenousbolus10
μ g
/ kgloadingdosetirofiban , theintracoronarygroupweregivencoronary10 μ g / kgloadingdose
tirofiban , thecontrolgroupweregivenconventionaltreatment.Results Thethrombolysisin
myocardialinfartionflow0 , 1 , 2ratiosafterPCIoftheintravenousgroup , coronarygroupwere
significantlylower ( P <0.05 ), the3ratiowassignificantlyhigher ( P <0.05 ) .Therewasno
significantdifferenceinmortalitybetweenthe3groups ( P >0.05 ) .Theincidencesofthedeath ,
refractoryischemia , malignantarrhythmia , againprimaryendpointofmyocardialinfarctionin
intravenousgroupandcoronaryarterygroupweresignificantlylowerthanthatinthecontrol
group ( P <0.05 ) .TheLeftventricularejectionfraction , E / A>1ratio , incidenceofbleeding
weresignificantlyhigher ( P <0.05 ), theplateletcountwassignificantlylessthanthatinthe
controlgroup ( P <0.05 ) .Conclusion Intravenousandintracoronaryloadingdoseoftirofibanare
abletoimprovethePCIprognosisofpatientswithacutemyocardialinfarction.

Key words: myocardialinfarction , tirofiban , administration , prognosis