Abstract: ( DepartmentofMedicine , theSecondHospitalofHebeiMedicalUniversity , Shijiazhuang 050000 , China )
[
Abstract ] Objective Toinvestigatethechangesofcontinuousadministrationofmetoprolol
tartratetabletsinsixdaysonthepharmacokineticofinrats.Methods Fortyratswererandomly
dividedintotwogroups with20ratsineachgroup.Eachratinthetestgroup wasgiven
metoprololtartrate ( 27mg /
kg
), andeachratinthecontrolgroupwasgivenequalvolumeof
distilledwaterorally , twicedailyfor6days.Onday7 , eachratintwogroupsrecievedasingle
doseof metoprololtartrate ( 27 mg /
kg
) .Bloodsamples weretakenatdifferenttimesafter
administrationfromtheinnercanthus.Theconcentrationsofmetoprololtartrateweredetermined
byultraperformanceliquidchromatography ( UPLC ) .Thepharmacokineticparametersofthetwo
groupswerecalculatedwithDAS2. 1. 1pharmacokineticsoftwareandwerecomparedwithSPSS
13. 1software.Results The mainpharmacokineticparametersinthetestgroupandcontrol
group : areaundercurve ( AUC ) 0-5h were ( 0. 84±0. 40 )
mg
· h
-1 · L -1 and (
0. 96±0.46 )
mg
· h
-1 ·
L
-1 ,
respectively ; AUC 0-∞ were (
0. 91±0.41 )
mg
· h
-1 · L -1 and (
1. 05±0. 50 )
mg
· h
-1 · L -1 ,
respectively ; halflife ( t 1 / 2 ) were (
1. 23±0.36 ) hand ( 1. 42±0.41 ) h , respectively ; T max were
(
0. 51±0.10 ) hand ( 0. 85±0.28 ) h , respectively ; V were ( 58.19±22.61 ) L / kgand ( 61. 54±

Key words: metoprolol tartrate, pharmacokinetics； ultra performance liquid chromatography, rats