Journal of Hebei Medical University

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Clinical analysis with 21 cases of primary hyperparathyroidism

  

  1. 1.Department of Thyroid Surgery, the Second Hospital of Hebei Medical University,
    Shijiazhuang 050000, China;2.Department of Urology, the Second Hospital of Hebei
    Medical University, Shijiazhuang 050000, China
  • Online:2016-04-25 Published:2016-05-18

Abstract: [
Abstract ] Objective Toinvestigateclinicalmanifestations , diagnosis methodandearly
detectionmeasuresand misdiagnosisreasonsofprimaryhyperparathyroidism ( PHPT ) andto
raiseawarenessofparathyroiddisease.Methods Theclinicaldataof21casesofpatientswith
PHPTwerecollectedandtheirclinicalfeatureswereanalyzed.Results Atotalof21PHPT
patientswerepathologicallydiagnosedwithparathyroidadenoma.Theirclinicalmanifestations
includedbonepain , osteoporosis , pathologicfractures , urinarycalculiandsoon.Beforesurgery ,
elevatedintactparathyroidhormonelevels werefoundin19cases ( 90.1% ), elevatedblood
calcium werefoundin18cases ( 85.7% ), reducedbloodphosphorus wasfoundin13cases
(
61.9% ) andelevatedbloodalkalinephosphatasewerefoundin11cases ( 52.4% ) .Thelesion
detectionratewas81.0% ( 17 / 21 ) byneckcolorDopplerultrasound.Thelesiondetectionratewas
53.3% ( 8 / 15 ) byneck CT.Thelesiondetectionrate was100.0% ( 21 / 21 ) byparathyroid
radionuclideimagingand95.2% ( 20 / 21 ) by neck ultrasoundcombined with bloodcalcium
examination.Allpatientsunderwentparathyroidresectioninaffectedside.Allthe21cases
appearedperioralandlimb numbness postoperatively and 5 cases ( 23.9% ) appearedlimb
convulsion.Conclusion Cliniciansshouldraiseawarenessofparathyroiddiseases.Theuseof neckcolorultrasoundcombined with bloodcalcium examinationhelpsthescreeningofthe
disease.Surgeryistheonlymeansoftreatingthedisease , andaccuratepositioningpreoperatively
isconducivetonarrowsurgeryproberangeandtominimizedamagetosurroundingtissues.

Key words: hyperparathyroidism , parathyroidneoplasms , diagnosis , therapy