Abstract: [ Abstract ] Objective Todetecttheclinicalefficacyandsafetyofneo-adjuvantchemotherapy
withnedaplatinand5-fluorouracil ( 5-FU ) forthepatientswithesophagealcancer.Methods A
totalof72patientswithesophagealcancerrandomlydividedintotreatmentgroup ( 36cases ) and
controlgroup ( 36cases ) .Treatmentgroupreceivedneo-adjuvantchemotherapywithnedaplatin
and5-FUfor2cyclesandunderwentoperation3-4weeksafterchemotherapy.Thepatientsof
controlgroup weretreated with operationalone.Theradicalresectionrate , postoperative
complicationrateandthree-yearsurvivalratewerecomparedbetweenthetwogroups.Results
Thepatientsoftwogroupsweresuccessfullycompletedtheoperation.Theradicalresectionrate ,
postoperativecomplicationrate , three-yearsurvivalrateofthetreatmentgroupwere88.9% ,
41.7% , 60.0% andthoseofcontrolgroup were69.4% , 36.1% , 34.3% , respectively.The
radicalresectionrateandthree-yearssurvivalratebetweenthetwogroupsweresignificantly
different , buttherewasnosignificantdifferenceinpostoperativecomplicationrate.Conclusion
Nedaplatininneo-adjuvantchemotherapyforesophagealcancercouldsignificantlyincreaseradical
resection rate and three-year survival rate and presented no negative influence on the postoperativecomplicationrate , whichisworthyofclinicalapplication.

Key words: esophagealneoplasms , fluorouracil , chemoradiotherapy, adjuvant