Abstract: ［Abstract］  Objective〖HTSS〗〓To explore the high risk factors  in infantile cholestatic hepatopathy(ICH).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The clinical data of 86 infants with cholestatic hepatopathy were reviewed and analyzed. Meanwhile, 100 cases who were hospitalized of the same term were as the control.  Children's gender, age, feeding history, history of jaundice in the neonatal period, stool color, skin yellow dye history, serum alanine, transaminase(ALT), serum total bile acids(TBA) were summarize. Logistic regression analysis was been applied to obtain the result.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The result of logistic regression analysis showed that breast feeding, pathological jaundice in neonatal period, the history of jaundice in skin or sclera and higher level of ALT are the high risk factors for ICH（P＜005）.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓As the disease causes of ICH, breast feeding, pathological jaundice in neonatal period, the history of jaundice in skin or sclera and higher level of ALT are the high risk factors. While artificial feeding are protective factors.

Key words: cholestasis, intrahepatic, liver diseases, infant, risk factors