Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the correlation between the level of inflammatory cells, inflammatory factors(CD4+T, CD8+T, Thl7, IL17) and pulmonary functions of patients with bronchial asthma.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Two hundred and sixtyeight patients with bronchial asthma were enrolled in this study. One hundred and fortytwo cases of moderate intermittentmild, 126 cases of moderate to severe and 60 cases of healthy subjects were collected as control group. ①The blood pH (pH), arterial oxygen partial pressure(PaO2), arterial oxygen saturation(SaO2), and arterial carbon dioxide pressure(PaCO2) were measured. ②The vital capacity (VC), the forced expiratory volume in one second/predicted value%(FEV1/Pre%) and peak expiratory flow(PEF) were measured for all participants. ③The levels of CD4+T, CD8+T, Thl7, IL17 in peripheral blood were detected. ④Correlation between the expression of CD4+T, CD8+T, Th17, IL17 and pulmonary functions were explored.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓①The PaCO2 value of the moderate to severe group and the intermittentmild group were significantly higher than that of the healthy control group(P＜005). The pH, PaO2 and SaO2 were significantly lower in the moderate to severe group than those in the intermittentmild group(P＜005). ②Compared with the control group, the pulmonary function indexes of the patients in the intermittentmild group and the moderate to severe group were significantly lower than those in the control group(P＜005). The pulmonary function indexes were significantly lower in the moderate to severe group than those in the intermittentmild group(P＜005). ③The levels of Th17, CD8+T, IL17 in the intermittentmild group and the moderate to severe group were significantly higher than those in control group. CD4+T cells were lower than those in control group. The levels of Th17, CD8+T, IL17 in the moderate to severe group were significantly higher than those in intermittentmild group, CD4+T cells were lower than those in the intermittentmild group(P＜005). ④CD4+T cell level was positively correlated with VC, FEV1/Pre and PEF in asthmatic patients. Th17, CD8+T and IL17 levels were negatively correlated with VC, FEV1/Pre% and PEF. ⑤The correlation between CD4+T, CD8+T, Th17, IL17 levels and pulmonary functions in the moderate and severe group were higher than those in the intermittentmild group.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The expression levels of CD4+T, CD8+T, Th17 and IL17 could be used as indicators for the in vivo changes of bronchial asthma. In the clinical diagnosis and treatment, we should give a scientific and reasonable treatment plan combined with the changes of the in vivo environment of the patients.

Key words: asthma, pulmonary function test, blood gas analysis