Abstract: ［Abstract］〓Objective〖HTSS〗〓To study the exact effect of levothyroxine and growth hormone in the treatment of dwarfism caused by hypothyroidism.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Eighty children with short stature caused by hypothyroidism were selected and randomly divided into control group(levothyroxine tablet treatment) and experimental group(levothyroxine tablet + growth hormone treatment) according to different treatment methods, 40 cases in each group. Growth velocity(GV), height standard deviation score(HtSDS), predicted adult height(PAH), bone age(BA) and serum osteocalcin(OC) levels were compared before and after treatment for 3 and 6 months. The changes of serum thyroxine(T4) levels were recorded before and after treatment.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The levels of GV, HtSDS, PAH and OC increased with time after treatment. There was no significant difference in GV, HtSDS, PAH and OC levels at 3 months of treatment. At 6 months of treatment, GV, HtSDS, PAH and OC levels in the experimental group were significantly higher than those in the control group. There were significant differences in the interactions among groups, time points, and between groups（P＜005）. There was no significant difference in the interaction between BA groups, time points and grouptime point interaction P＞005). T4 levels in both groups increased significantly after 3 months of treatment(P＜005). However, there was no significant difference in the interaction between T4 groups, between groups and between time points after treatment P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Levothyroxine combined with recombinant human growth hormone in the treatment of dwarfism caused by hypothyroidism can effectively promote the growth of height, and significantly increase the level of thyroid hormone.

Key words: growth disorders, thyroxine, growth hormone