Abstract: ［Abstract］〓Objective〖HTSS〗〓To investigate the risk factors about reduced atorvastatin compliance in patients with cerebral infarction secondary prevention.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 546 patients with acute cerebral infarction were followed up for 3 months. All patients were divided into two groups according to the decrease of atorvastatin compliance or not. The following factors were compared between the two groups, including sex, age, neurological function, the number of patients with different daily doses of atorvastatin and incidence of following subjective causes, included economic problems, substitution of traditional Chinese medicine, abnormal guidance, forgetting and misunderstandings, adverse reactions and lack of confidence. Risk factors of reduced compliance of atorvastatin in patients with secondary prevention of cerebral infarction were analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓At the end of the investigation, 21 patients lost their visits and 525 patients completed the study, among which 281 patients (53.5%) had decrease of atorvastatin compliance. There was no significant difference on sex, age, neurological function and the number of patients with different daily doses of atorvastatin between two groups(P＞005). The incidence of economic problems, substitution of traditional Chinese medicine, abnormal guidance, forgetting and misunderstandings, adverse reactions and lack of confidence in the decrease of atorvastatin compliance group were significantly higher than those in the not decrease of atorvastatin compliance group(P＜005). Economic problems, substitution of traditional Chinese medicine, abnormal guidance, forgetting and misunderstandings, adverse reactions and lack of confidence were the risk factors about reduced atorvastatin compliance by multivariate Logistic regression analysis. 
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Taking effective measures against the above subjective causes may reduce or even eliminate the decrease of atorvastatin compliance during the secondary prevention of cerebral infarction.

Key words: brain infarction； atorvastatin, medication adherence