Abstract: ［Abstract］〓Objective〖HTSS〗〓To compare the differences in clinical characteristics between hepatitis B virus related hepatocellular carcinoma(HBVHCC) and alcohol related HCC（alcoholHCC）, as well as evaluate whether these clinical characteristics are associated with the subtype of HCC.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 271 cases of HCC patients were divided into two groups as HBVHCC(n=215) and alcoholHCC(n=56). The clinical data including age, gender, alanine aminotransferase（ALT）, aspartate aminotransferase（AST）, γglutamyl transpeptidase（GGT）, total bilirubin（TBIL）, albumin（ALB）, ChildPugh classification, alphafetoprotein（AFP）, subtype of image classification, tumor quantity, and portal vein tumor thrombosis were evaluated in the two different groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓There was no difference of distribution frequency referring to age between HBVHCC and alcoholHCC(P＞005), whereas the distribution frequency for gender was significantly different in these two subtypes with more male patients in alcoholHCC（P＜005）. There was no difference of distribution frequency in terms of TBIL, ChildPugh classification between the two subtypes(P＞005), whereas ALT， AST， GGT, ALB and AFP were significantly different. The level of GGT increased significantly in alcoholHCC subtypes(P＜005). Compared with alcoholHCC, a lower level of ALB(P＜0.05) and increased AFP， ALT， AST were found in HBVHCC(P＜005). Imaging analysis including subtype of image classification, tumor quantity, and portal vein tumor thrombosis were performed in 104 cases of HBVHCC and 29 cases of alcoholHCC, no difference exist in the two groups（P＞005）.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓More Male patients in alcoholHCC subtype demonstrated the influence of lifestyle on disease. The fact that alcohol is the mitochondrial enzyme inducer of hepatocyte to promote the synthesis and release of GGT could explain the increased GGT levels in alcoholHCC. The low ALB in HBVHCC implied that the HBV could severely destroy the synthesis function of liver. Increased ALT and AST level in HBVHCC suggest that liver function was damaged seriously. The obviously increased AFP in HBVHCC implied the different signal transduction pathway initiated by these two types. The two subtypes of HCC are indistinguishable in terms of image classification, tumor quantity, and portal vein tumor thrombosis.

Key words: liver neoplasms, hepatitis B, alcohol