Abstract: 〗［Abstract］ Objective〖HTSS〗〓To explore the clinical efficacy of high frequency oscillatory ventilation and synchronized intermittent mandatory ventilation in the treatment of neonatal respiratory failure, and the influence on the levels of CC16 and KL6 in neonates.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One hundred and thirty cases of neonates with respiratory failure were randomly divided into observation group(n=65, 12 cases of premature infants, 53 cases of fullterm infants) and control group(n=65, 12 cases of premature infants, 53 cases of fullterm infants ). The observation group was treated with high frequency oscillatory ventilation, the control group was treated with synchronized intermittent mandatory ventilation, The clinical efficacy of two groups of preterm infants and fullterm infants were compared, and the 0 h, 24 h and 72 h blood gas indexes of two groups were detected, and the changes of serum CC16 and KL6 before and after treatment and the occurrence of adverse reactions were observed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The overall clinical effective rate was 908%(59/65) in the observation group, which was significantly higher than that in the control group(80.0%, 52/65). The effective rate of the two groups of fullterm infants was better than that of premature infants(P＜005). The oral feeding time, ventilator use time and hospitalization time of the observation group were significantly shorter than the control group(P＜005). After mechanical ventilation, the OI, RI and PaCO2 of the two groups showed a gradual decline trend. The PaO2 and PaO2/FiO2 of the two groups showed a gradual increase, but the decrease and increase of the observation group were larger. The two groups were between the groups and the time. There were significant differences in the interaction between the groups and between the groups(P＜005). The serum levels of CC16 and KL6 in the two groups were significantly lower than those before treatment(P＜005). The levels of CC16 and KL6 in the observation group were significantly lower than those in the control group after treatment(P＜005). The incidence of adverse reactions such as pulmonary hemorrhage, ventilatorassociated pneumonia, and lower respiratory tract infection in the observation group were significantly lower than that in the control group(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Noninvasive high frequency oscillatory ventilation in the treatment of neonatal  with respiratory failure can significantly improve the blood gas index, reduce inflammation, reduce the level of KL6 and CC16, improve the lung injury and with less adverse reaction.

Key words: respiratory insufficiency, infant, newborn, respiration, artificial, treatment outcome