Abstract: Objective To explore the short-term and long-term efficacy of minimally invasive ligation, tissue adhesive injection(TAI) combined with partial splenic embolization(PSE) and traditional pericardial devascularization plus splenectomy(Hassab′s procedure) in the prevention and treatment of esophagogastric variceal rebleeding. 
Methods Eighty-six patients with esophagogastric variceal bleeding in our hospital were enrolled in the study. The patients were divided into minimally invasive group(n=43) and Hassab group(n=43) according to the random number table method. Minimally invasive group was treated with ligation, TAI combined with PSE, and Hassab group was treated with Hassab′s procedure. The portal vein blood flow(trunk diameter and blood flow velocity of portal vein), hypersplenism indexes ［white blood cells(WBC), platelet(PLT)］ and liver function(Child-Pugh score) were compared between two groups before surgery and at 3 months after surgery. The success of hemostasis and improvement of varicose veins, occurrence of complications at 3 months after surgery, short-term and long-term rebleeding rates and survival rate at 12 months after surgery were recorded. 
Results At 3 months after surgery, the trunk diameter and blood flow velocity of portal vein in two groups were decreased compared with those before surgery(P＜0.05), while the hypersplenism indexes(WBC, PLT) were increased compared with those before surgery(P＜0.05), and there were no significant differences between the groups(P＞0.05). The Child-Pugh score in two groups was decreased compared with that before surgery(P＜0.05), and the score was lower in minimally invasive group than in Hassab group(P＜0.05). The success rates of hemostasis in the two groups were both 100.00%. There were no significant differences in the improvement of varicose veins, short-term and long-term rebleeding rates and survival rate at 12 months after surgery between two groups(P＞0.05). The total incidence rate of complications at 3 months after surgery in minimally invasive group was significantly decreased compared with that in Hassab group(P＜0.05). 
Conclusion Ligation, tissue glue injection and PSE is noninferior to traditional Hassab in the prevention and treatment of esophagogastric variceal rebleeding. However, it has smaller trauma than Hassab, and has positive significance for improving liver function.

Key words: esophageal and gastric varices, hemorrhage, surgical procedures, minimally invasive