Abstract: Objective  To observe the clinical efficacy of oral propranolol in the treatment of infantile hemangioma. 
Methods  Retrospective analysis was performed on 300 infants with hemangioma diagnosed in the Outpatient Department of our hospital. Among them, 150 in the observation group were treated with propranolol, and 150 patientsin the control group were treated with prednisolone therapy. Two groups of children had regular outpatient follow-up visit, and direct observation, manual measurement, color Doppler ultrasound or MRI and other methods were performed to observe the hemangioma area, color change, texture and adverse reactions. 
Results  The tumor size of observation group was significantly smaller than that of the control group, and the time of spontaneous regression was shortened, suggesting significant difference(P＜0.001). Furthermore, the effective rate of the observation group(94.00%) was significantly higher than that of the control group(82.67%), and the adverse reactions of the observation group were significantly lower than those of the control group(P＜0.01). 
Conclusion  Oral propranolol is effective in the treatment of infantile hemangioma without obvious adverse reactions.

Key words: hemangioma, propranolol, treatment outcome