Abstract: Objective To analyze the expression and correlation of aquaporin 4(AQP4), fatty acid synthase(FASN), and epithelial kinase A2(EphA2) in meningioma tissue. 
Methods A total of 43 meningioma patients were selected, their meningioma tissue was surgically removed and enrolled as meningioma group, and 43 meningioma tissues removed by trauma surgery were selected. Relative expression of AQP4 was measured by quantitative real-time polymerase chain reaction(PCR), and relative expression of FASN and EphA2 was detected by immunohistochemistry. The expression and correlation of AQP4, FASN, and EphA2 in meningioma tissues were analyzed. 
Results Compared with normal meningeal tissues, the expressions of AQP4, FASN, and EphA2 in meningioma tissues were increased(P＜0.05). The relative expressions of AQP4, FASN, and EphA2 were correlated with meningioma grade, peritumoral edema, and bone invasion(P＜0.05). Among them, the relative expressions of AQP4, FASN, and EphA2 in patients with grade Ⅱ, grade Ⅲ meningiomas, peritumoral edema, and bone invasion were significantly increased(P＜0.05). Correlation analysis showed that the expression of AQP4 and FASN in meningioma tissues was positively correlated(r=0.506, P＜0.001); The expression of FASN and EphA2 was positively correlated(r=0.528, P＜0.001); The expression of AQP4 and EphA2 was positively correlated(r=0.507, P＜0.001). ROC curve analysis showed that compared with the single diagnosis of AQP4, FASN, and EphA2, the combination of the three had the highest diagnostic value for meningioma(P=0.001). 
Conclusion The relative expression of AQP4, FASN, and EphA2 in meningioma is increased, and is related to the pathological characteristics of the patient. The clinical evaluation of the disease can be made based on the relative expression.

Key words: meningioma, aquaporin 4, fatty acid synthase, epithelial kinase A2