Abstract: Objective To analyze the effect of high flux hemodialysis(HFHD) combined with cisapride on inflammatory factors, renal function indexes and clinical efficacy in patients with chronic renal failure(CRF). 
Methods A total of 152 patients with CRF who were treated were enrolled, and randomly divided into observation group(n=76) and control group(n=76). The control group was treated with HFHD, and the observation group was treated with cisapride on the basis of the control group. The inflammatory factors, renal function indexes, gastrointestinal hormones, clinical efficacy and treatment safety of the two groups were evaluated and compared. 
Results After treatment, the levels of calcitonin gene-related peptide(CGRP), serum fibroblast growth factor 23(FGF-23) and heat shock protein 47(HSP47) in the observation group were lower than those in the control group(P＜0.05). After treatment, renal function indexes［β2-microglobulin(β2-MG), urea nitrogen(BUN) and serum creatinine(Scr)］ in the observation group were lower than those in the control group(P＜0.05). After treatment, the levels of gastrin(GAS), vasoactive intestinal peptide(VIP) and motilin(MOT) in the observation group were higher than those in the control group(P＜0.05). After treatment, the total effective rate was 92.11%(70/76), which was higher than that ［80.26%(61/76)］ in the control group(P＜0.05). The incidence of adverse reactions in the two groups were 14.47%(11/76) and 10.53%(8/76) respectively(P＞0.05). 
Conclusion HFHD combined with cisapride is effective in the treatment of patients with chronic CRF. It can reduce the level of inflammatory reaction, and improve the level of gastrointestinal hormone and the renal function, with good safety.

Key words: kidney failure, chronic, renal dialysis, treatment outcome