Abstract: ObjectiveTo investigate the predictive value and correlation of cholecystokinin(CCK), connexin 43(Cx43) and glucagon-like peptide-1(GLP-1) in gastric emptying in patients with type 2 diabetic gastroparesis(DGP). 
MethodsIn total, 127 patients with type 2 diabetes with abnormal gastric function were selected, including 49 patients with functional dyspepsia as dyspepsia group, and 78 patients with diabetic gastroparesis as gastroparesis group. Another 50 healthy patients with normal gastric function who underwent physical examination during the same period were selected as control group. The gastric half-emptying time was measured in all subjects. CCK, Cx43 and GLP-1 levels were detected by enzyme-linked immunosorbent assay, and solid gastric emptying ability was detected by radionuclide. The predictive value of CCK, Cx43 and GLP-1 in gastric emptying in patients with type 2 DGP, and the correlation of CCK, Cx43 and GLP-1 were analyzed. 
ResultsThe levels of CCK and Cx43 in dyspepsia group and gastroparesis group were lower than those in control group, the levels of GLP-1 were higher than those in control group, and the gastric half-emptying time was longer than that in control group; the levels of CCK and Cx43 in gastroparesis group were lower than those in dyspepsia group, the levels of GLP-1 were higher than those in dyspepsia group, and the gastric half-emptying time was longer than that in dyspepsia group(P＜0.05). The combined detection of CCK, Cx43 and GLP-1 had higher predictive value for gastric emptying in patients with type 2 DGP. CCK was positively correlated with Cx43(r=0.482; P＜0.001), CCK was negatively correlated with GLP-1(r=-0.356; P＜0.001), and Cx43 was negatively correlated with GLP-1(r=-0.619; P＜0.001). 
ConclusionCCK, Cx43 and GLP-1 are abnormally expressed in type 2 DGP, which has certain value in predicting type 2 DGP.

Key words: diabetes mellitus, type 2, gastroparesis, gastric emptying, prediction