Abstract: Objective To observe the clinical efficacy of pars plana vitrectomy (PPV) combined with endoscopic cyclophotocoagulation (ECP) and panretinal photocoagulation (PRP) for angle-closure neovascular glaucoma (NVG) secondary to proliferative diabetic retinopathy (PDR). 
Methods  Twenty-one patients (21 eyes) diagnosed with angle-closure NVG secondary to PDR were enrolled in this study. Intravitreal injection of anti-vascular endothelial growth factor （anti-VEGF） was performed after completing the relevant examinations, which led to regression of neovascularizations (NVs)on the iris and in the angle,and all the eyes underwent PPV combined with ECP and PRP, and also combined with phacoemulsification (PHACO), intraocular lens (IOL) implantation, if the patients were complicated with cataract. The duration of follow-up was more than 12 months. The best corrected visual acuity(BCVA)， intraocular pressure (IOP), the mean number of IOP-lowering drugs, changes in the anterior segment, surgical success rate, and the occurrence of complications were comparatively observed and recorded at 1 week, 1 month, 3 months, 6 months, and 12 months after surgery. 
Results Compared with that before surgery, the log MARBCVA of the affected eyes at 12 months after surgery was improved in 9 eyes(43%), stabled in 12 eyes (57%), and decreased in no eyes. Eight patients were followed up for 18 months, 6 of them (75%) maintained their visual acuity, while 2 of them (25%) decreased at the last follow-up compared with that at 12 months. The mean IOP at 1 week, 1 month, 3 months, 6 months, and 12 months after surgery was lower than that before surgery, and the mean IOP at 1 month, 3 months, 6 months, and 12 months was lower than that at 1 week after surgery, suggesting significant differences(P＜0.05). The number of IOP-lowering drugs used at 1 month, 3 months, 6 months, and 12 months after surgery was less than that before surgery, and the difference was statistically significant(P＜0.05). At 12-month follow-up,10 eyes were a complete success, 7 eyes were a conditional success, while 4 eyes were a failure at 12 months after surgery, and the overall success rate was 81%. Inflammatory exudation of the anterior chamber occurred in 3 eyes, but it was fully absorbed after local treatment. 
Conclusion PPV combined with ECP and PRP in the treatment of angle-closure NVG secondary to PDR is safe and effective.

Key words: diabetic retinopathy, glaucoma, neovascular, ophthalmologic surgical procedures