Abstract: Objective To study and analyze the occurrence of postoperative cognitive dysfunction (POCD) and its influencing factors in patients with severe craniocerebral injury (SCCI). 
Methods A total of 150 patients with SCCI treated in Marine Corps Hospital were selected as the research subjects， and POCD rate of all the patients was analyzed. POCD rates of patients with different ages， genders， education levels， injury sites， Glasgow Coma Scale (GCS) score at admission， number of injury sites， causes of injury， smoking history, drinking history， complications and underlying diseases were compared， and the influencing factors of POCD of patients with SCCI were analyzed with multivariate Logistic regression analysis. 
Results Among 150 patients with SCI, 111 patients developed POCD， with an incidence rate of 74.00%, there was no significant difference in the rate of POCD in patients with different genders， causes of injury， smoking history and drinking history（P＞0.05）. POCD rates of patients aged ＞50 years years， primary school education， injury site of frontal lobe， GCS score of 3 to 5 points at admission, number of injury sites ≥ 2, complications and underlying diseases were significantly higher than those of other patients（P＜0.05）. Multivariate Logistic regression analysis showed ＞50 years of age， primary school education， injury site of frontal lobe， GCS score of 3 to 5 points at admission, number of injury sites ≥ 2, complications and underlying diseases were the influencing factors of POCD of patients with SCCI（P＜0.05）. 
Conclusion Patients with SCCI have a high rate of POCD， which has various influencing factors. Therefore, they can provide major reference for the intervention of POCD of patients with SCCI. 

Key words: craniocerebral injury, postoperative cognitive dysfunction, influencing factors