Abstract: Objective To investigate the influencing factors and intervention strategies for the poor mental state of patients with differentiated thyroid cancer(DTC) after surgery. 
Methods A total of 128 DTC patients who underwent surgery in the Department of Head and Neck Surgery of our hospital were selected as the research subjects. Their anxiety status was evaluated by self-rating anxiety scale(SAS) and the influencing factors of anxiety were analyzed. 
Results The incidence of anxiety in 128 patients was 39.84%. The SAS evaluation showed mild anxiety(54.18±3.01) points, accounting for 32.03%; moderate anxiety(64.22±3.13) points,accounting for 6.25%; severe anxiety(71.07±1.55) points, accounting for 1.56%.Logistic regression analysis showed that female, unmarried status, unawareness of the condition,family monthly income per capita＜3 000 yuan, self-paid medical expenses, and high risk of disease recurrence were the major influencing factors of anxiety after DTC(P＜0.05). 
Conclusion Female gender, unmarried status, unawareness of the condition, family monthly income per capita＜3 000 yuan, self-paid medical expenses and high risk of disease recurrence are the major influencing factors of anxiety of patients after surgery for DTC. Nursing such as social support, psychological intervention and incentive intervention should be selectively carried out to improve the psychological state of patients.

Key words: thyroid neoplasms, poor mental state, influencing factors