Abstract: Objective To investigate the expressions of nasal fractional exhaled nitric oxide (nFeNO), osteopontin (OPN) and specific immunoglobulin E (sIgE) in patients with allergic rhinitis (AR) and their value in auxiliary diagnosis of asthma. 
Methods A total of 228 AR patients in our hospital were selected as the observation group, including 187 patients with pure AR and 41 patients with AR combined with asthma; 45 healthy people undergoing physical examination during the same period were selected as the control group. The levels of nFeNO, OPN, and sIgE between two groups were compared, and the correlation between the levels of nFeNO, OPN, and sIgE in AR patients and total nasal symptom score (TNSS) score was analyzed. Logistic regression analysis was used to analyze the independent influencing factors of AR with asthma, and receiver operating characteristic (ROC) curve analysis was used to analyze the diagnostic value of nFeNO, OPN and sIgE for AR complicated with asthma. 
Results The levels of nFeNO, OPN and sIgE in the observation group were higher than those in the control group (P＜0.05). The levels of nFeNO, OPN and sIgE in AR patients were positively correlated with the TNSS score (P＜0.05). Logistic regression analysis showed that the increased levels of nFeNO, OPN and sIgE were independent risk factors for AR complicated with asthma (P＜0.05). The ROC curve showed that the AUC value of nFeNO, OPN and sIgE in combination to diagnose AR complicated with asthma was 0.829, which was higher than that of single indicator in diagnosis. 
Conclusion The levels of nFeNO, OPN and sIgE in AR patients are positively correlated with the TNSS score, and are of great value in prediction and auxiliary diagnosis of AR complicated with asthma. 

Key words: rhinitis, allergic, seasonal, nitric oxide, asthma