Abstract: Objective To explore the correlation between free fatty acids (FFA), placental growth factor (PLGF), and results of non-invasive hemodynamic monitoring in patients with preeclampsia to enhance the early diagnosis and management of preeclampsia. 
Methods Eighty patients with preeclampsia were selected as the observation group, and 75 normal pregnant women undergoing prenatal examinations during the same period were selected as the control group. The levels of FFA, PLGF, and hemodynamic indicators were compared between the two groups, and the correlation between FFA, PLGF levels, and hemodynamic indicators in the observation group was analyzed. 
Results The serum PLGF levels in the observation group were lower than those in the control group ［(62.03±18.45) ng/L vs. (106.95±12.34) ng/L］, while the FFA levels were higher than those in the control group ［(0.77±0.66) mmol/L vs. (0.59±0.57) mmol/L］ (P＜0.05). The mean arterial pressure (MAP) in the observation group was higher than that in the control group ［(103.56±11.12) mmHg vs. (84.87±9.54) mmHg］, as were the systemic vascular resistance (SVR) ［(1,467.45±487.12) dyne·s·cm5 vs. (1 032.45±274.45) dyne·s·cm5］, systemic vascular resistance index (SVRI) ［(2 596.58±790.69) dyne·s·cm5·m2 vs. (1 762.45±537.42) dyne·s·cm5·m2］, and tissue perfusion ［(33.22±5.23) koh-m-1 vs. (30.45±5.87) koh-m-1］ levels (P＜0.05). The cardiac index (CI) ［(3.12±0.56) L·min-1·（m2）-1 vs. (3.45±0.71) L·min-1·（m2）-1］, cardiac output (CO) ［(5.54±1.13) L/min vs. (6.23±1.15) L/min］, stroke index (SI) ［(34.36±7.74) mL/beat·m2 vs. (39.12±8.24) mL/beat·m2］, stroke volume (SV) ［(62.35±14.54) mL/beat vs. (69.22±15.11) mL/beat］, arterial compliance index (ACI) ［（91.87±34.89）10-2·s-2 vs.（117.12±42.78）10-2·s-2］, and vascular index (VI) ［（51.45±18.87）10-3·s-1 vs.（67.14±20.53）10-3·s-1］ levels in the observation group were lower than those in the control group (P＜0.05). There were no significant differences in the changes in the left ventricular function index and systolic time ratio between the two groups (P＞0.05). Spearman correlation analysis showed that FFA levels were positively correlated with the severity of preeclampsia (r=0.615, P＜0.05), while PLGF levels were negatively correlated with the severity of preeclampsia (r=-0.587, P＜0.05). In the observation group, MAP, SVR, SVRI, and tissue perfusion were positively correlated with FFA levels and negatively correlated with PLGF levels. Conversely, CI, CO, SI, SV, ACI, and VI were positively correlated with PLGF levels and negatively correlated with FFA levels. 
Conclusion In patients with preeclampsia, FFA levels are elevated, and PLGF levels are decreased. There is a certain correlation between the levels of FFA and PLGF and the results of non-invasive hemodynamic monitoring, which can aid in the early diagnosis of preeclampsia. 

Key words: eclampsia, fatty acids, placenta growth factor