Abstract: Objective To study the efficacy and safety of percutaneous nephrolithotomy lithotripsy(PCNL)by micro-channel and small channel for kidney stone patients.Methods The study enrolled 210 kidney stone patients who were divided randomly into observation group 110 cases and control group 100 cases.The patients in observation group were treated by micro-channel PCNL,while those of control group with PCNL by small channel.Intraoperative indicators operative time,blood loss,perfusion fluid volume,bleeding cases,and postoperative hospital stay,postoperative complications,stone clearance rate,serum creatinine,hemoglobin were compared between two groups.Results The blood loss,perfusion fluid volume of observation group were significantly less than those of control group(P <0.01);the ratio of large bleeding in observation group was less than that in control group,2.7% (3/110)vs 12.0% (12/100)(P <0.01).Postoperative hospital stay,postoperative complications in observation group were less than those in control group(P <0.05 or <0.01);Stone clearance rate in observation group were higher than in control group were 92.7% (102/110)vs 71.0% (71/100)(P <0.01 ).Conclusion The efficacy of PCNL by micro-channel for kidney stone patients is good,and it can improve the therapeutic effect and prognosis.The method is worthy of promotion in clinic.

Key words: kidney calculi, lithotripsy, nephrostomy, percutaneous