Abstract: Objective To investigate the effect of initiation time on renal replacement therapy(RRT) for clinical prognosis of patients with non diabetic end stage renal disease (NDNESRD).Methods A total of 89 NDNESRD patients who started the first dialysis were classified into early-start group or late-start group according to estimated glomerular filtration rate(eGFR).The primary outcome was patient survival,and the secondary outcomes were hospitalization,cardiovascular events,vascular access complications,change of dialysis modality, and peritonitis.The follow-up period was five years.Results The survival rate showed no significant difference in the first,the third and the fifth years between the two groups(P =0.166, 0.088,0.067 ).Hospitalization (35.7% vs 38.3%,P = 0.667 ),cardiovascular events (14.3% vs 10.6%,P = 0.089),vascular access complications (21.2% vs 28.1%,P = 0.682)and peritonitis (22.2% vs 26.7%,P =0.541)were no difference between the two groups.Conclusion There was no significant clinical benefit comparing early versus late initiation of RRT.

Key words: nephrosis, renal dialysis, prognosis