Abstract: Objective To retrospectively analyze 418 clinical isolates of Pseudomonas aeruginosa,observe the department distribution and drug resistance characteristics,and take effective control for multi-drug resistant P.aeruginosa.Methods Vitek 2 compact automated microbial identification and susceptibility for identification and susceptibility testing were used. Data were analyzed according to CLSI 2012 breakpoints with WHONET 5.6 sofeware.Results 418 isolates of P.aeruginosa were mainly from the respiratory medicine department,ICU and neurosurgery department.The samples from the sputum of respiratory tract were predominant, representing 78.72%.The drug resistance of P.aeruginosa to Amikacin was the lowest as 4.79%, followed by Cefepime and Ceftazidime,respectively,25.36% and 29.19%,and the rest of antimicrobial drug resistance rate over 30%,of which the highest Aztreonam was 50.72%. Conclusion P. aeruginosa is mainly from respiratory tract specimens higher resistance. Antimicrobial resistance surveillance plays an important role in controlling hospital infection.The monitoring and management measures should be strengthened.

Key words: Pseudomonas aeruginosa, anti-bacterial agents, drug resistance