Impact of 20 mg atorvastatin calcium on hsCRP and MMP9 of asymptomatic carotid plaque patients

doi:10.3969/j.issn.10073205.2016.07.003

Abstract

Abstract: [
Abstract ] Objective Toobservethelong-termeffectoflowdoseatorvastatinontheserum
high-sensitivityC-reactiveprotein ( hsCRP ) and matrix metalloproteinase-9 ( MMP-9 ) among
neurologicallyasymptomaticpatients withultrasounddefinedunstablecarotidatherosclerotic
plaque.Methods Atotalof73caseswererandomlydividedintotreatmentgroup ( n =38 ) and
controlgroup ( n =35 ) .Thetreatmentgroupreceivedaspirin100mgplusatorvastatin20mgper
day , whereasthecontrolgrouponlytookaspirin100mgperday.ThelevelsofserumhsCRP
,
MMP-9 , totalcholesterol ( TC ), weremeasuredbeforeandaftertreatmentin6and12months.
Andtheendeventsandadversereactionsofthe2groupswererecorded.Results Therewasno
differenceinthelevelsofserum TC , lowdensitylipoproteincholesterol ( LDL-C ), hsCRPand
MMP-9incontrolgroup.Intreatmentgroup , thelevelsofserumTC , LDL-C , hsCRPandMMP-
9atthe6monthsand12monthsoffollow-upwerelowerthanthatbeforetreatment ( P <0.05 ) Conclusion Low-doseatorvastatinnotonlycouldregulateTC , butalsoreducethelevelsof
seruminflammatory mediators MMP-9andhsCRP , inhibitinflammatoryreactionandstable
plaque , therebypreventingtheoccurrenceofischemiccerebrovasculardisease.

Key words: plaque, atherosclerotic； atorvastatin calcium, Creactive protein

XIE Bingchuan1， LIU Huimiao1， SHI Jun2，SUI Xiaozhe3， GU Ping1*， WANG Mingwei1. Impact of 20 mg atorvastatin calcium on hsCRP and MMP9 of asymptomatic carotid plaque patients[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2016.07.003.

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Impact of 20 mg atorvastatin calcium on hsCRP and MMP9 of asymptomatic carotid plaque patients

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