Abstract: 〗［Abstract］  Objective〖HTSS〗〓To investigate the effects of high sensitiveC reactive protein(hsCRP) and low density lipoprotein(LDL) levels in patients with acute cerebral infarction, and to investigate the effects of hsCRP and LDL on the acute cerebral infarction and its clinical significance.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Three hundred and seventyfour cases of cerebral infarction were selected as the case group and 60 healthy volunteers were normal control group. In the case group, 158 patients with largeartery atherosclerosis(LAA), 171 patients with small artery occlusion(SAO) and 45 cases with cardioembolism(CE) were divided into three groups according to TOAST classification. All the subjects were given 3 mL of venous blood in the early morning of the next day, and the levels of serum hsCRP and LDL were measured.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓National Institute of Health stroke scale（NIHSS） score, systolic blood pressure and diastolic blood pressure of LAA, SAO and CE group were significantly higher than those of control group. The NIHSS score of LAA group and CE group was higher than that of SAO group, and the systolic blood pressure of LAA group and SAO group was higher than that of CE group. LAA, SAO group were higher than the control group and CE group. SAO group was higher than the control group, LAA, SAO, CE group of hypertension, hyperlipidemia, heart disease rate was higher than the control group. The incidence of heart disease in CE group was higher than that in LAA group and SAO group. The levels of serum hsCRP in LAA, SAO and CE group were higher than those in LAA group and SAO group, and the level of serum hsCRP in LAA group was higher than that in SAO group. The level of serum LDL in LAA and SAO group was higher than that in control group(P＜005). The levels of serum hsCRP in patients with acute cerebral infarction were positively correlated with LDL and NIHSS scores(rs=0.164, 0.183, P＜005). Logistic regression analysis showed that systolic blood pressure and hsCRP were risk factors for cardioembolism.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓In the TOAST subtype, serum hsCRP can be used as a risk factor for CE, and it is an indicator of the etiology of early diagnosis of cerebral infarction. LDL is expected to become a specific biochemical index of LAA, which has important clinical value for early prediction of LAA.

Key words: brain infarction, Creactive protein, lipoproteins, LDL