Abstract: ［Abstract］  Objective〖HTSS〗〓To observe the microdisorders of thyroid axis in patients with type 2 diabetes mellitus(T2DM) and obesity, and their impact on insulin resistance.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Two hundred patients with T2DM and first discovery of obesity were selected as T2DM group. One hundred obesity persons were selected as normal glucose tolerance(NGT) group at the same period. The levels of free triiodothyronine(FT3), free thyroxine(FT4), thyroid stimulating hormone(TSH), homeostasis model of assessment for insulin resistance(HOMAIR) and hemoglobin A1c(HbA1c) were observed in T2DM and NGT group before and after treatment. The levels of FT3, FT4,TSH,HOMAIR and HbA1c were observed in T2DM group with different HbA1c levels, and the correlation between thyroid hormone and HOMAIR were also observed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The levels of FT3 and FT4 in T2DM group were significantly lower than those in NGT group, and the levels of TSH, HOMAIR and HbA1c were significantly higher than those in NGT group(P＜005). The FT3 and FT4 levels decreased with the increase of HbA1c level. And the levels of TSH, HOMAIR in T2DM group increased with the increase of HbA1c level(P＜005). After treatment, the levels of FT3 and FT4 were significantly increased compared with before treatment, while, the levels of TSH, HOMAIR and HbA1c were significantly lower compared with those before treatment(P＜005). The levels of FT3 and FT4 were negatively correlated to the levels of HOMAIR(r=-0.781, -0.564, P＜005), and there were positively correlated between TSH and HOMAIR levels(r=0.648, P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓There are thyroid axis micro disorder and insulin resistance in patients with T2DM and obesity, and thyroid axis micro disorder is correlated significantly to insulin resistance. Treatment of T2DM is helpful in alleviating the thyroid dysfunction and insulin resistance.

Key words: diabetes mellitus, type 2, obesity, thyroid hormones