Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the association of level of serum soluble Eselectin(sEselectin) with cognitive deficits in type 2 diabetes mellitus(T2DM) patients.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Enzymelinked immunosorbent assay is used to determine the sEselectin level in 80 cases of patients and 80 controls without T2DM from the Medical Examination Center. The data on demographic characteristics including age, gender, education, body mass index(BMI) and duration of illness were recored. Clinical parameters including highsensitivity Creactive protein(hsCRP), Homocysteine(Hcy), fasting plasma glucose(FPG), fasting serum lisulin(FIN), hemoglobin A1c(HbA1c), total cholesterol(TC), Triglycerides(TG), high density lipoprotein(HDLC), low density lipoprotein(LDLC) and homeostasis model assessmentinsulin resistance(HOMAIR) were collected. Cognitive performance was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS) which consists of five subtests including immediate memory, visuospatial constructional, language, attention and delayed memory; and the scores from the above five subtests were scaled together to create a total score. Difference in RBANS scores was compared between the T2DM group and control group. T2DM patients were divided into high sEselectin level group and low sEselectin level group according to the median level of sEselectin, and the difference in cognitive function was compared between the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Serum FPG, HbA1c,TC, TG, LDLC, hsCRP, Hcy, HOMAIR levels, BMI, and the level of sEselectin of the T2DM patients were higher than those of the controls(P＜005). RBANS scores were lower in the T2DM patients than in the controls on the total score and all subtests(P＜005) expect for constructional of RBANS. In the T2DM patients, immediate memory, visuospatial constructional, language, delayed memory and total score of the patients with low sEselectin were lower than those of the patients with high sEselectin(P＜005). In T2DM patients, sEselectin concentration was positively correlated with HOMAIR and negatively correlated with immediate memory, language, attention, delayed function and total score, the difference was statistically significant（P＜005）. 
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓sEselectin may be involved in the occurrence and development of cognitive dysfunction in patients with T2DM patients.

Key words: diabetes mellitus, type 2, soluble Eselectin, cognition