Abstract: ［Abstract］ Objective〖HTSS〗〓To investigate the relationship between human telomerase reverse transcriptase(hTERT) gene polymorphism rs2736100 and tumor in Asian population. 
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓According to the inclusion and exclusion criteria, relevant literature were searched based on key words in Chinese and English databases. Documents that met the requirements were screened, and related data were extracted. Stata 12.0 statistical software was used to merge and analyze the extracted data. Meanwhile, odds ratio(OR) and its 95% confidence interval(95%CI) were calculated.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Totally 34 casecontrol studies were included, including 47 148 tumor patients and 75 673 controls. Metaanalysis results showed that hTERT gene polymorphism rs2736100 could significantly increase tumor genetic susceptibility in Asian populations(B vs A, OR=1.25，95%CI=1.20-1.29， P=0000), (BB vs AA, OR=1.56, 95%CI=1.45-1.67, P=0000）, (AB vs AA, OR=1.22, 95%CI=1.17-1.28, P=0000）, (AB+BB vs AA, OR=1.30, 95%CI=1.24-1.37, P=0000), (BB vs AB+AA, OR=1.39, 95%CI=1.32-1.47, P=0000). Moreover, 36 815 lung cancer patients and 64 149 controls were included in this study. Metaanalysis results indicated that rs2736100 could significantly increase lung cancer susceptibility in Asian populations(B vs A, OR=1.28, 95%CI=1.23-1.32, P=0000）, (BB vs AA,OR=1.64, 95%CI=1.52-1.76, P=0001）, (AB vs AA, OR=1.27, 95%CI=1.21-1.33, P=0015), (AB+BB vs AA, OR=1.35, 95%CI=1.28-1.42, P=0001), (BB vs AB+AA, OR=1.42, 95%CI=1.35-1.50, P=0030）.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓In Asian populations,rs2736100 polymorphism of hTERT gene is a risk factor for tumor susceptibility.

Key words: neoplasms, reverse transcriptase polymerase chain reaction, human telomerase, Metaanalysis