Abstract: Objective To investigate the regulation of lncRNA small nucleolar host gene12 (SNHG12) on proliferation, cell cycle, invasion, migration and apoptosis of cervical cancer SiHa cells. 
Methods RT-PCR was performed to detect SNHG12 expression in cervical cancer tissues and cell lines HaCaT, C33A, SiHa and CasKi. CCK8, flow cytometry assay, Transwell, cell wound scratch assay and Tunel cell apoptosis were adopted to detect the regulatory abilities of SNHG12 on proliferation, cell cycle, invasion, migration and apoptosis of SiHa cells, and also to detect the subcutaneous tumor growth of cervical cancer. Immunohistochemistry was used to detect Ki67 antibodies. 
Results Overexpressed SNHG12 was obviously elevated in cervical cancer tissues and all cell lines. SNHG12 up-regulation could promote proliferation, cell cycle, invasion, migration and inhibit apoptosis of SiHa cells. SNHG12 could promote subcutaneous tumor growth, while interference with SNHG12 could generate inhibitory effects. The positive signal of SNHG12 was highly enhanced, while silencing SNHG12 produced the opposite result. 
Conclusion SNHG12 could facilitate SiHa cell proliferation, cell cycle, invasion, migration and suppress apoptosis, thereby participating in the pathological process of cervical cancer. 

Key words: cervical neoplasms, small nucleolar host gene12, cell proliferation