Abstract: Objective  To analyze the effect of nasal nebulization of budesonide suspension combined with clarithromycin on the treatment of chronic rhinosinusitis(CRS), nasal polyps and bronchial asthma. 
Methods  A total of 128 patients with CRS and bronchial asthma undergoing endoscopic sinus surgery at the Fourth Central Hospital of Baoding City(Hebei Province), and the Department of Otolaryngology, the Second Hospital of Hebei Medical University were selected as the research subjects and divided into clarithromycin group(n=64) and combination group(n=64) according to the lottery method. Two groups of patients were treated with FESS operation, after conventional treatment of bronchial asthma before operation. The clarithromycin group was treated with clarithromycin, while the combination group was treated with nasal aerosol inhalation of budesonide suspension on the basis of clarithromycin group. The improvement time of clinical symptoms, lung function of lower airway, eosinophils(EOS) count, neutrophil/lymphocyte ratio(NLR), platelet/lymphocyte ratio(PLR), asthma control test(ACT) score, soluble interleukin-2 receptor(sIL-2R), interferon- γ（IFN- γ, the levels of soluble CD23(sCD23) and interleukin-4(IL-4) as well as the curative effect were measured. 
Results  Compared with clarithromycin group, the improvement time of moist rales, wheezing, asthma and cough in combination group was shorter(P＜0.05). Compared with clarithromycin group, FEV1, FVC and PEF in combination group were higher(P＜0.05). Compared with clarithromycin group, EOS count, NLR, PLR, sIL-2R, sCD23, and IL-4 levels were decreased in combination group, while ACT score and IFN-γ levels were increased(P＜0.05). Compared with clarithromycin group, the total response rate of combination group was higher(P=0.023). 
Conclusion  Patients with CRS, nasal polyps and bronchial asthma were treated with nasal nebulization of budonide suspension combined with clarithromycin, which significantly improved clinical symptoms and lung function, and had a significant effect.

Key words: nasal polyps, asthma, budesonide, clarithromycin