Abstract:

Objective  To investigate the effect of radiotherapy on the radiation-induced heart disease(RIHD) indicators in patients with breast cancer.

Methods  The literature was searched in the PubMed data base, Wanfang medicine, domestic medical research journals and biomedical literature, and the effect of radiotherapy regimen on evaluation indicators of RIHD was searched. The key indicators were cardiac troponin I(cTnI), creatine kinase isoenzyme-MB(CK-MB), N-terminal pro-B-type natriuretic peptide(NT-pro BNP) and brain natriuretic peptide(BNP).Meta-analysis was performed using Rev Man 5.2 software based on the collected literature.

Results  The retrieved literature was screened according to the criteria of research subject, method and disease type, and finally 8 literature meeting the criteria was included, with low publication bias. The results of meta-analysis showed that cTnI, CK-MB and BNP after radiotherapy were significantly higher than those before radiotherapy, suggesting significant differences(P＜0.05). There was no significant difference in NT-pro BNP before and after radiotherapy(P＞0.05). The results of sensitivity test revealed that the literature had little heterogeneity and high reference value.

Conclusion  Radiotherapy can significantly change the cTnI, CK-MB and BNP of patients with breast cancer, resulting in RIHD. The progress of research on the optimization of radiotherapy regimen for breast cancer patients should be further followed up to minimize RIHD. CTnI, CK-MB and BNP can be used as good predictors of RIHD in radiotherapy for breast cancer patients, thereby providing reference for timely diagnosis and prevention of RIHD in patients with breast cancer.

Key words: breast neoplasms, radiotherapy, radiation-induced heart disease