Abstract: Objective  To investigate the expression of ovarian adenocarcinoma amplified long non-coding RNA(lncRNA OVAAL), microRNA(miR)-335 and tripartite motif 14(TRIM14) in endometrial carcinoma(EC) and their correlation with clinical characteristics. 
Methods  A total of 86 EC patients in our hospital were selected as the case group, and 86 patients with endometrial polyps(EP) during the same period were selected as the control group. The expressions of lncRNA OVAAL, miR-335 and TRIM14 in EC cancer tissues, adjacent tissues and endometrial polyps were detected. Their relationship with clinical characteristics of EC and their predictive value for the risk of EC recurrence were analyzed. 
Results  The expression of lncRNA OVAAL and TRIM14 in cancer tissue was higher than that in adjacent tissue and EP tissue, while the expression of miR-335 was lower than that in adjacent tissue and EP tissue(P＜0.05). The expression of lncRNA OVAAL and TRIM14 in EP tissues was higher than that in adjacent tissue, and the expression of miR-335 was lower than that in adjacent tissue(P＜0.05). The expression of lncRNA OVAAL, miR-335 and TRIM14 in cancer tissue was related to FIGO stage, histological grade, depth of myometrial invasion, lymph node metastasis, vascular invasion, and pathological type(P＜0.05). The expression of lncRNA OVAAL and TRIM14 in cancer tissues of patients with recurrence was higher than that of patients without recurrence, and the expression of miR-335 was lower than that of patients without recurrence(P＜0.05). After adjusting for FIGO stage, histological grade, depth of myometrial invasion, lymph node metastasis, vascular invasion, and extent of lymph node dissection, the expression of lncRNA OVAAL, miR-335 and TRIM14 were the influencing factors of EC recurrence(P＜0.05). The AUC of lncRNA OVAAL, miR-335 and TRIM14 combined to predict EC recurrence was greater than that of single index. 
Conclusion  The abnormal expression of lncRNA OVAAL, miR-335 and TRIM14 in cancer tissue is related to FIGO stage, histological grade, depth of myometrial invasion, lymph node metastasis, vascular invasion, and pathological type in EC patients, which can be used as important indicators for predicting postoperative recurrence.

Key words: carcinoma, endometrioid, RNA, untranslated, tripartite motif proteins ,