Abstract: Objective  To investigate the correlation of diffusion-weighted imaging (DWI), and intravoxel incoherent motion diffusion-weighted imaging (IVIM) parameters with tumor marker levels in children with glioma and their diagnostic value. 
Methods  A total of 89 children with suspected glioma diagnosed in our hospital were selected. With pathological examination as the gold standard, 62 children with definitive diagnosis of glioma were selected as the observation group, and the remaining 27 children were selected as the control group. All subjects were examined by DWI and IVIM, and the levels of carbohydrate antigen 125 (CA125), epidermal growth factor (EGF) and carcinoembryonic antigen (CEA) were detected by enzyme-linked immunosorption assay (ELISA). The levels of apparent dispersion coefficient (ADC), relative cerebral blood volume (rCBV), true water molecular dispersion coefficient (D), perfusion related dispersion coefficient (D*), CA125, EGF and CEA levels were compared in children with different conditions. The correlation between each indicator and the disease type was compared. The correlation between DWI, IVIM parameters and tumor markers in children with glioma was compared. The diagnostic value of DWI and IVIM parameters in glioma was analyzed. 
Results  Compared with the control group, the ADC value and D parameters of the observation group were higher, while the rCBV and D* parameters were lower (P＜0.05). Compared with children with low-grade glioma, children with high-grade glioma had higher ADC values, D parameters and serum CA125, EGF and CEA levels, but lower rCBV and D* parameters (P＜0.05). The levels of rCBV and D* were negatively correlated with the type of disease (r=-0.395, P＜0.001; r=-0.405, P＜0.001), while ADC value, D, CA125, EGF, CEA levels were positively correlated with disease type (r=0.432, P＜0.001; r=0.441, P＜0.001; r=0.432, P＜0.001; r=0.409, P＜0.001; r=0.431, P＜0.001); ADC value (r=0.409, P＜0.001; r=0.415, P＜0.001; r=0.423, P＜0.001); D parameter was positively correlated with the levels of tumor markers CA125, EGF and CEA (r=0.417, P＜0.001; r=0.43, P＜0.001; r=0.409, P＜0.001); RCBV was negatively correlated with the levels of tumor markers CA125, EGF and CEA (r= -0.402, P＜0.001; r=-0.413, P＜0.001; r=-0.387, P＜0.001); D* level was negatively correlated with the levels of tumor markers CA125, EGF and CEA(r=-0.411, P＜0.001; r=-0.406, P＜0.001; r=-0.399, P＜0.001). Compared with ADC value, rCBV, D and D *, the combined detection of the four indicators was more effective in the diagnosis of glioma (P<0.05). 
Conclusion  DWI and IVIM parameters have certain correlation with tumor markers in children with glioma, and have certain diagnostic value for the disease types of children with glioma.

Key words: glioma, diffusion weighted imaging, tumor marker